Bioadhesive polymeric platforms for transmucosal drug. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue bioadhesives may consist of a variety of substances, but proteins and carbohydrates feature prominently. Baking layer of the buccal films was prepared using ethyl cellulose and adheres to the buccal film. We believe the information it contains to be correct but cannot guarantee its accuracy or completeness. This serves as essential scientific support for the subsequent chapters, each of which is devoted to the applications. Our msc in polymers for advanced technologies aims to train, or retrain scientists for a variety of careers in polymer science and polymer related fields. Chapter 1 introduction bioadhesive drug to delivery. It is the users obligation to evaluate and use this product safely and to comply with all applicable laws and regulations. Mucoadhesive drug delivery systems 3 the contact between the mucoadhesive and the mucous membrane, with spreading and swelling of the formulation, initiating its deep contact with the mucus layer hagerstrom, 2003. The use of mucoadhesive polymers in buccal drug delivery. Dissolution studies all film formulations were evaluated for nonpharmacopoeial industry specified tests. Biopolymers can be complex and nice introduction to materials science, chapter 15, polymer structures university tennessee, dept. Bioadhesive and mucoadhesive polymers authorstream presentation.
A focus on mucoadhesive polymers and their application in. Polymers for contact adhesives mallard creek polymers. Today we added a clever teaching tool to the shop that can help designers, engineers, and students to. Polymers showing 289297 of 561 results sort by popularity sort by average rating sort by newness sort by price. Polypropylene general description polypropylene is an economical material that offers a combination of outstanding physical. If the product you are looking to buysell is not on any lists chances are it may not be listed either call us or fill in a product inquiry page to. Mechanics of magnetoactive polymers iowa state university. One way to modify clay is by exchanging organic ammonium cations for inorganic cations from the clays surface sherman, 1999. Cyclodextringrafted polymers functionalized with phosphanes. The potential of a mucoadhesive polymer as an ophthalmic vehicle is evaluated within the rabbit. Bioadhesives are natural polymeric materials that act as adhesives.
While biopolymers rank highly in terms of green design, they exhibit relatively large. The course covers a broad range of polymer topics including synthesis, modification, characterisation of polymers, polymer properties, behaviour and applications. Soda pdf merge tool allows you to combine two or more documents into a single pdf file for free. To make the two compatible, the clays polarity must be modified to be more organic to interact successfully with polymers hay, 2000. Download the free pdf converter and create pdf files from any application with pdf creator. This free online tool allows to combine multiple pdf or image files into a single pdf document. Definition polymer organic compound, natural or synthetic, with high molecular weight made of repetitive structural units large size chains formed from the covalent union of various monomer units macromolecule plastic 1. Pdfcreator allows you to convert files to pdf, merge and rearrange pdf files, create digital signatures and more.
In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane. Rearrange individual pages or entire files in the desired order. A1 polymers, coimbatore manufacturer of pppolypropylene. Pdf merge combinejoin pdf files online for free soda pdf. Polymers selected for this edition of the handbook of polymers include all major polymeric materials used by the plastics and other branches of the chemical industry as well as specialty polymers used in the electronics, pharmaceutical, medical, and space fields. A wide range of formulations has been proposed for the delivery of small molecules, but comparatively few have found their way onto the market. Structure of polymers the time has come, the walrus said, to talk of many things. Distinguished b of series for optical fiber coatings y their carefully balanced combination of high adhesion to the core, and high modulus, these uv cured coatings are setting new.
Five polymers, namely carbopol, hpmc, sodium alginate, nacmc and guar gum, were used at different polymer to drug ratios. Pdfcreator download for free, download pdf printer, pdf writer, pdf. Best of all, pdf creator is absolutely free for anyone to use. The international journal of adhesion and adhesives draws together the many aspects of the science and technology of organic polymeric adhesive materials, from fundamental research and development work to industrial applications. Evaluation of mucoadhesive polymers in ocular drug.
The name accurately depicts the importance of plastics since it is being used in all industries universally raza et al. Means of improving the mucoadhesive properties of drug delivery system article pdf available may 2010 with 5,377 reads how we measure reads. Polymers and concentration of polymers were optimized for mucoadhesive buccal film. Mechanics of magnetoactive polymers by yi han a dissertation submitted to the graduate faculty in partial fulfillment of the requirements for the degree of doctor of philosophy major. Detecting polymers in material products table of contents introduction simple tests preliminary examination density melting point behavior on heating introduction it can be very difficult, if not impossible, to achieve complete identification of most polymer products. Sales specifications and technical data sheets are available on request. Like buccal cavity, nasal cavity also provides a potential site for the development of formulations where mucoadhesive polymers can play an important role. Many of our online forms, reports, regulations and publications are only in portable document format pdf. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water approximately 95% within its composition.
First generation mucoadhesive polymers anionic polymers polyacrylic acids carbomers, sodium alginate cationic polymers chitosan nonionic polymers cellulose derivatives hydroxyl, carboxyl or amine groups on the molecules favours adhesion formulation challenges due to hydrophilicity and limited solubility in other solvents. Development of novel mucoadhesive delivery systems are being undertaken so as to understand the various mechanism of mucoadhesion and improved permeation of active agents. Polymers polymers are the giant molecules of chemistry. Introduction to materials science, chapter 15, polymer structures university tennessee, dept. My polymers of products are optical fiber primary coatings with low refractive index and high transmission. The various sites where mucoadhesive polymers have played an important role include buccal cavity, nasal cavity, rectal lumen, vaginal lumen and gastrointestinal tract. Abstract the goal of any drug delivery system is to provide a therapeutic amount of drug to the. Today, polymers are commonly used in thousands of products as plastics, elastomers, coatings, and adhesives. Used for bonding laminates or foam, contact adhesives demonstrate autoadhesion. The tablets, prepared with a mucoadhesive cup and a core formula, showed a high bioadhesive force and adhered to the buccal mucosa for 8 h, exhibiting, in vitro, a zeroorder drug release profile. This means that when two dry films are brought together they will bond and not separate. Polymers that bind to specific receptor site on tile self surface. Advances in mucoadhesion and mucoadhesive polymers.
In case of the homogeneous system, the dependence follows the theoretical prediction of the percolation theory. Chapter 1 introduction to bioadhesive drug delivery 3 in biological systems, four types of bioadhesion figure 1. Consequently, bioadhesive polymers have extensively been employed in transmucosal drug delivery systems. Synthesis, properties and biodegradability of the main classes and new families of synthetic polymers are discussed below. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will. Polymers used in the mucoadhesive drug delivery system tahsin akhtarali shaikh, dattatraya monohar shinkar, ravindra bhanudas saudagar department of pharmaceutics, kts rgs ollege of pharmacy, anjaneri, nasik, 4222, maharashtra, india.
The pdf file can be easily downloaded to your computer, enabling you to view it offline at your convenience. They make up about 80% of the organic chemical industry with products produced at approximately 150 kg of polymers per person annually in the united states. Although typical properties are given, eastman makes no representation that shipments will conform to the value given. Polymers that become sticky when placed in water and owe their mucoadhesion to stickiness.
Clever teaching tool for plastic moulding added to the shop. Polymers that adhere through nonspecific, non covalent interactions that is primarily electrostatic in nature although hydrogen and hydrophobic bonding may be significant. Theories of mucoadhesion the phenomen a of bioadh esion occur b y a compl ex mechanism. Polymer whose fundamental property is plasticity thermoplastic. Chitosan is gaining importance in the development of mucoadhesive drug delivery system because of its good biocompatibility, biodegradability and non toxic nature. The small buildingblock molecules are called monomers. Polymerization is the process in which monomer units are linked by chem ical reaction to form long chains. The book opens by presenting important background information on polymer chemistry and physicochemical characterization of polymers. The residence time of a particulate matter in the nasal mucosa varies between 15. Reflux apparatus other documents experimental procedure, report template introduction chemically, plastics are chainlike molecules of high molecular weight, called polymers and are built up from simpler chemicals, the individual links, called monomers.
Biodegradation or biotic degradation is a specific property of certain plastic materials that is, of the polymers these materials are made of. Conductive polymer materials with low filler content. Due to their various qualities, such as lightness, chemical and microbial stability, nondegradable polymeric materials are routinely. The nasal mucosal layer has a surface area of around 150200 cm 2. It is a cationic polymer polysaccharide jian hwa et al. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic. Of shoesand shipsand sealingwax of cabbagesand kings lewis carroll, through the looking glass 1872 shoes, ship, sealing wax, cabbage, and a king the many things listed by the walrus are actually very similar in chemical composition.
This product list contains many of the polymers we deal with. In recent years, compounds have been increasingly recognized by the automotive, electrical and electronic. Synthetic polymers are a mainstay of modern life, but nature also makes polymers. We can even add a colorant, additive, flame retardant, uv resistance, durability or wear resistance package to the compound developed for you. Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane.
Introduction to materials science, chapter 15, polymers. Biodegradable polymers are a special class of polymer that breaks down after its intended. Polymers being adaptable can be easily moulded as per requirement. Inorganic polymer chemistry pdf 30p this note covers the following topics. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug may be released at the site for an extended period of time. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract gitract, the vagina, the lung, the eye, etc.
963 332 961 864 42 580 598 64 390 1517 944 1431 1151 872 696 976 1408 799 672 516 214 536 894 540 727 811 168 126 1104 1472 330 885 1348 1211